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LifeSource Cryobank: Only Company in U.S. to Extract and Store Stem Cells Directly from Bone Marrow

Photo courtesy of iStockphoto, Image# 1135046A privately-owned, FDA-registered, state of the art laboratory - LifeSource Cryobank, LLC - is committed to ensuring the safety and integrity of the stem cells it store in a totally secure environment. Located in Covington, Louisiana, LifeSource opened its doors in September 2007 and is the only company in the U.S. to extract and store stem cells directly from bone marrow.Utilizing an advanced medical technique, doctors at LifeSource Cryobank, LLC can extract, purify, expand and store a type of stem cells directly from bone marrow. Because these stem cells give rise to or participate in the formation of bone, muscle, cartilage, blood vessels and other tissues and organs, they are far superior to hematopoietic stem cells that can only regenerate new blood cells.This summer, Michael Drury became the first person in the United States to have his stem cells banked via the new extraction method. Developed by LifeSource Scientific Director Jose Minguell, Ph.D., and overseen by its Medical Director, Gabriel Lasala, M.D., Drury had stem cells aspirated directly from bone marrow in his hip. The stem cells were then isolated and multiplied before being stored in the cryopreservation facility.The researchers are also using these procedures to execute three Federal Drug Administration reviewed clinical trials to treat lower limb ischemia (blockage to the vessels of the legs), coronary ischemia (blockage to the vessels of the heart) and damage to heart muscle from heart attack. Over the last nine months, more than twenty people have undergone the patent-pending procedure as part of the trials.Find out more at LifeSource Cryobank, LLC.[Press release provided by Jill Willie of Gallinghouse & Associates.]See full article.
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Gene Therapy for Chronic Pain Goes on Clinical Trial

Scientists from the University of Michigan will begin a phase 1 clinical trial for the treatment of cancer-related painusing gene therapy: a novel gene transfer vector injected into the skin to deliver a pain-relieving gene to the nervous system.In this groundbreaking clinical trial, the investigators will use a vector created from herpes simplex virus (HSV) - the virus that causes cold sores - to deliver the gene for enkephalin, one of the body's own natural pain relievers."In pre-clinical studies, we have found that HSV-mediated transfer of enkephalin can reduce chronic pain," says David Fink, M.D., Robert Brear Professor and chair of the department of neurology at the U-M Medical School. Fink developed the vector with collaborators and will direct the study.
The researchers are recruiting 12 patients with intractable pain from cancer for this study. For more information, contact the U-M Cancer AnswerLine, 800-865-1125.Image: Caption: The gene transfer vector (left) is injected into the skin in the area of pain (red line, right). From the skin, the vector is carried into sensory nerves and releases the inhibitory neurotransmitter locally in the spinal cord (red oval). Credit: University of MichiganSee full article.
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Photo courtesy of iStockphoto, Elena SchweitzerAgricultural researchers have developed several new pepper cultivars that were more well adapted to climatic conditions and plant diseases of the Southwest and to U.S. consumer preferences. To date they have new cultivars of jalapeno, serrano, Habanero, poblano ancho, bell and other fresh pepper plants that produce higher yields, with the size, shape, color, capsaicin (the active "heat" ingredient) level and nutritional content American consumers prefer.The team has established the first-known poblano pepper production in Texas through a partnership with San Antonio-based Constanzo Farms and is collaborating with other large producers in New Mexico and Arizona.They have licensed two hot pepper cultivars in the past three years and have provided stock seed for commercial production, as well as providing large quantities of trial seed to pepper growers in Texas, New Mexico and Arizona.See full article.
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China says 294,000 children fell ill from tainted milk (AFP)
AFP - China said Monday that a total of 294,000 children had fallen ill from consuming dairy products tainted with the industrial chemical melamine, with 154 of them still in serious condition.
Insulin-Producing Cells from Embryonic Stem Cells

Insulin-Producing Cells from Embryonic Stem Cells

Photo courtesy of iStockphoto, Gary CavinessSingapore researchers have developed pure insulin-producing cells from mouse embryonic stem cells (ESCs). The resulting cells have the same sub-cellular structures as the insulin-producing cells naturally found in the pancreas, were highly effective in treating diabetes in the mouse model.Experiments by Dr Lim and Dr Li's group showed that when transplanted into diabetic mice with high blood glucose levels, the pure insulin-producing cells would cause the blood glucose levels of the animals to decrease. In addition, it was discovered that none of the diabetic mice involved in the transplants developed teratoma, a type of tumour often associated with ESCs, which could complicate their use in therapeutic treatment. Furthermore, the pure insulin-producing cells managed to retain their insulin-production and glucose-sensing capacity over time.These findings, published in two papers in the July 31 and August 8 online version of the journal Stem Cell Research, provide proof of principle that the same strategy could be applied to human ESCs to obtain similar pure insulin-producing cells.See full article.
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Non-Invasive Blood Test for Fetal Genetic Anomalies

Photo courtesy of iStockphoto, Sylvia CookResearchers have developed a new prenatal blood test that accurately detected Down syndrome and two other serious chromosomal defects in a small study of 18 pregnant women. The test scan fetal DNA present in the mother's blood to detect chromosomal anomalies, particularly with chromosomes 21, 18, and 13, which are associated with severe birth defects.Employing a "shotgun sequencing" strategy using a high-throughput gene sequencing technology to identify millions of unique sequence "tags" in the fetal DNA, the scientists were able to correctly identify the 12 women who carried aneuploid fetuses and the six whose pregnancies were normal. Their results matched those of amniocentesis or CVS test that were done on the women. The research group is now planning a larger scale study. The cost of the test is estimated to be about $300, with DNA sequencing accounting for the majority of the overall cost.

Source
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Protein Biomarkers in Urine for Bovine Spongiform Encephalopathy (BSE)

6961047Photo courtesy of iStockphoto, Rob BroekResearchers have identified proteins in urine samples which may be used as an indicator of the presence and progress of Bovine Spongiform Encephalopathy (BSE) disease in cattle.The scientists analysed the proteins in urine samples taken from four infected and four healthy cows of the same age over the course of the disease. The proteins from the healthy and infected samples were compared using a technique called two-dimensional differential-gel electrophoresis (2-D DIGETM)In these preliminary results a single protein was able to distinguish between those infected and control animals. In addition, the relative abundance of a set of proteins could accurately determine how far the disease had advanced.
The researchers say these findings, published in the journal Proteome Science, may be used to develop a biomarker test for the diagnosis and monitoring of disease progression in BSE and related transmissible spongiform encephalopathies. SourceSee full article.
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Photo courtesy of iStockphoto, Alasdair ThomsonIn small scale trials, sweet potatoes grown in Maryland and Alabama has been shown to yield two to three times as much carbohydrate for fuel ethanol production as field corn grown in the same areas. in fact, the sweet potato carbohydrate yields approached the lower limits of those produced by sugarcane, the highest-yielding ethanol crop.It is however unclear whether sweet potatoes may be a viable alternative as biofuel source. Although they require less pesticides and fertilizer than corn, planting and harvesting incurs higher labor costs.

SourceSee full article.
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Photo courtesy of iStockphoto, Pali RaoA new animal study indicates that the degree of change in blood triglyceride levels following a fatty meal may indicate susceptibility to diet-induced obesity. The researchers suggest that based on these findings, a simple blood test may be designed to identify those at risk for obesity.In the study, published in the International Journal of Obesity, Friedman and lead author Hong Ji, PhD, screened rats for vulnerability to diet-induced obesity by measuring the increase in blood triglyceride levels following a single high-fat meal. They then fed the rats a diet high in fat over the next four weeks.The researchers were able to predict which animals would become obese over the four-week period by examining the earlier metabolic response to the high-fat meal: the smaller the triglyceride change, the greater the weight gain.
The researchers hopes to determine whether such a blood test is also an effective predictor of future weight gain in humans.See full article.
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Gut Microorganisms May Help Prevent Onset of Diabetes

Photo courtesy of iStockphoto, Silvia JansenYale researchers have found new supporting evidence to the so-called "hygiene hypothesis" - the theory that a lack of exposure to parasites, bacteria and viruses in the developed world may lead to increased risk of diseases like allergies, asthma, and other disorders of the immune system.In an animal study published in Nature, they found that exposure to certain non-pathogenic gut microorganisms helped prevent the onset of Type I diabetes in non-obese diabetic mice. From the report:Non-obese diabetic (NOD) mice develop the disease at different rates after natural breeding, depending upon the environment where they are kept. Previous research has shown that NOD mice exposed to killed (i.e., non-active) strains of tuberculosis or other disease-causing bacteria are protected against the development of Type I diabetes. This suggests that the rapid "innate" immune response that normally protects us from infections can influence the onset of Type 1 diabetes.In the Nature paper, teams led by Li Wen at Yale and Alexander V. Chervonsky at the University of Chicago showed that NOD mice deficient in innate immunity were protected from diabetes in normal conditions. However, if they were raised in a germ-free environment, lacking "friendly" gut bacteria, the mice developed severe diabetes. NOD mice exposed to harmless bacteria normally found in the human intestine were significantly less likely to develop diabetes, they reported.See full article.
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FDA defends U.S. infant formula (Reuters)
Reuters - The U.S. Food and Drug Administration defended the safety of infant formula sold in the United States on Friday despite tests that found the chemical melamine in one brand and a related compound in another.
Flood Tolerant Rice Varieties Passes Field Trials
Flod Tolerant Rice Varieties Passes Field Trials

Flod Tolerant Rice Varieties Passes Field Trials

Photo courtesy of iStockphoto, Thammarat KaosombatSeveral submergence-tolerant or "waterproof" rice varieties have passed field trials recently, and are now close to official release by national and state seed certification agencies in Bangladesh and India, according to reports.A specific gene called Sub1A has been isolated and using marker-assisted breeding techniques, and has been shown to confer tolerance to normally intolerant rice plants, enabling them to recover and yield well even after up to 2 weeks of complete submergence. The potential impact of these new flood-resistant varieties is expected to be enormous, considering the rice farming regions that suffer major floods each year. These new Sub1 varieties are NOT genetically modified organisms (GMOs), and are therefore not subject to the regulatory testing that can delay release of GMOs for several years.See full article.
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