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Cardiosphere-Derived Stem Cells for Treatment of Heart Disease

Photo courtesy of iStockphoto, Aaliya LandholtDuring the recently held Southern California BioMedical Council (SoCalBio or SCBC) 10th Investor Conference, biotech firm Capricor Inc presented their Cardiosphere-derived Stem Cells or CDC technology, and the multi-billion dollar market potential for heart therapies using CDC. "CDCs are the perfect stem cells to treat heart attacks and chronic heart failure" said Foellmer [President and CEO]. " Our stem cells are easily accessible from the patient themselves, readily grown in large numbers, and have proven themselves extremely safe. Unlike embryonic stem cells, there are no ethical or moral quandaries. And unlike other adult stem cells, such as bone marrow stem cells, our CDCs actually regrow cardiac muscle and vasculature. In short, CDCs have great potential for patients with a recent heart attack or chronic heart failure and we eagerly look forward to our imminent clinical trials."Capricor Inc. is headquartered in Los Angeles, California, and specializes in discovering, developing, and commercializing biotherapeutics for the treatment of heart diseases. See their products currently under clinical trials.See full article.
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Giant Knotwood Extract Regalia Biopesticide

Marrone Organic Innovations, Inc. has launched Regalia® SC, a new biopesticide for controlling both fungal and bacterial disease in a wide range of fruit, ornamental and vegetable crops.The EPA-registered product is an extract of giant knotweed, Reynoutria sachalinensis, which effectivelycontrols powdery mildew, bacterial diseases, rusts, gray mold and other crop diseases. Compoundsthat are extracted from the knotweed have been proven to stimulate the crops' natural defense systemagainst plant pathogens.Regalia is said to prevent these crop diseases by "switching on the plant's own natural defense mechanisms so plants produce and accumulate higher levels of natural proteins and other compounds that inhibit disease development." According to their press release (pdf file), Regalia will be initially available for use on vegetables and ornamentals, but for the 2009 season, grapes, tree fruits and other crops will be a focus.See full article.
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Aquatic Garden Plants In WasteWater Treatment

Photo courtesy of iStockphoto, Miguel LamielIn a report published in HortScience, researchers show the potential of constructed wetlands as a simple, low-technology method for treating agricultural, industrial, and municipal wastewater. They investigated the nitrogen and phosphorus removal potential by a vegetated, laboratory-scale subsurface flow system. Instead of traditional wetland plants, however, they used commercially available aquatic garden plants, with promising results:Over an 8-week period, five commercially available aquatic garden plants received a range of N and P (0.39 to 36.81 mg·L-1 N and 0.07 to 6.77 mg·L-1 P) that spanned the rates detected in nursery runoff. Whole plant dry weight was positively correlated with N and P supplied. Highest N and P recovery rates were exhibited by Thalia geniculata f. rheumoides Shuey and Oenenathe javanica (Blume) DC. 'Flamingo', Phyla lanceolata (Michx.) Greene also had high P recovery rates. The potential exists for using SSF CWs to concomitantly produce aquatic garden plants and attenuate nutrients in a sustainable nursery enterprise.They conclude that aquatic garden plants are aesthetic and economically viable alternatives to traditional wetland plants in constructed wetlands.See full article.
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Seamless replication of data and results to an existing customer-managed Symyx database.
Protein Biomarkers in Urine for Bovine Spongiform Encephalopathy (BSE)

Protein Biomarkers in Urine for Bovine Spongiform Encephalopathy (BSE)

6961047Photo courtesy of iStockphoto, Rob BroekResearchers have identified proteins in urine samples which may be used as an indicator of the presence and progress of Bovine Spongiform Encephalopathy (BSE) disease in cattle.The scientists analysed the proteins in urine samples taken from four infected and four healthy cows of the same age over the course of the disease. The proteins from the healthy and infected samples were compared using a technique called two-dimensional differential-gel electrophoresis (2-D DIGETM)In these preliminary results a single protein was able to distinguish between those infected and control animals. In addition, the relative abundance of a set of proteins could accurately determine how far the disease had advanced.
The researchers say these findings, published in the journal Proteome Science, may be used to develop a biomarker test for the diagnosis and monitoring of disease progression in BSE and related transmissible spongiform encephalopathies. SourceSee full article.
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Photo courtesy of iStockphoto, Tammy Peluso Scientists have identified a compound called largazole, produced by cyanobacteria that grow on coral reefs off the coast of key largo links

, that may have potentials as an anti-cancer drug.Largazole, discovered and named by Luesch for its Florida location and structural features, seeks out a family of enzymes called histone deacetylase, or HDAC. Overactivity of certain HDACs has been associated with several cancers such as prostate and colon tumors, and inhibiting HDACs can activate tumor-suppressor genes that have been silenced in these cancers.Following promising results in initial laboratory tests, animal tests are currently being planned.See full article.
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Poly-D-Lysine Matrix for Growing Animal-Free Stem Cells

Scientists have developed an alternative to animal-based materials such as Matrigel-coated plates for culturing the stem cells, which produce cells that are cells unsuitable for medical use. First, they identified a specific signaling pathway, called Rho-Rock, which the hESCs use during colony formation and which plays an important role in physical interactions between hESCs. When this pathway is blocked, researchers found that the normal colony formation of hESCs was considerably impaired, and that the hESCs maintained their pluripotency. In the study, sato links

's group extensively screened various types of scaffold materials in combination with Y27632, a chemical compound that blocks the Rho-Rock pathway, and found that the Matrigel coating could be replaced with "poly-D-lysine," a chemically synthesized ECM. The major advantages of poly-D-lysine over Matrigel are that poly-D-lysine is completely animal-free, easy to handle, and its quality is consistent."We found that the growth of the hESCs under this novel culture condition was almost identical to the growth of hESCs on Matrigel-coated culture plates, with no compromise in pluripotency," Sato said.
The group is now working on producing animal-free "induced pluripotent stem (iPS) cells" - pluripotent stem cells artificially derived from adult cells without using embryos.Photo: hESCs grown on poly-D-lysine-coated plate in defined culture media with Y27632. Photo credit: Sato lab, UC Riverside.See full article.
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Photo courtesy of iStockphoto, Bradley MasonResearchers have identified five protein biomarkers for oral squamous cell carcinoma, a form of oral cancer,found in the saliva. Researchers collected saliva samples from 64 patients with oral squamous cell carcinoma and 64 healthy patients.Five candidate biomarkers were successfully validated using immunoassays: M2BP, MRP14, CD59, profilin and catalase.The presence of these biomarkers confirmed the presence of oral cancer 93 percent of the time."I believe a test measuring these biomarkers will come to a point of regular use in the future," Hu said. "We have demonstrated a new approach for cancer biomarker discovery using saliva proteomics."Researchers are currently working on a device to detect these biomarkers, a potential clinical tool for noninvasive diagnosis of oral cancer in the future.
See full article.
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Gene Therapy for Chronic Pain Goes on Clinical Trial

Scientists from the University of Michigan will begin a phase 1 clinical trial for the treatment of cancer-related painusing gene therapy: a novel gene transfer vector injected into the skin to deliver a pain-relieving gene to the nervous system.In this groundbreaking clinical trial, the investigators will use a vector created from herpes simplex virus (HSV) - the virus that causes cold sores - to deliver the gene for enkephalin, one of the body's own natural pain relievers."In pre-clinical studies, we have found that HSV-mediated transfer of enkephalin can reduce chronic pain," says David Fink, M.D., Robert Brear Professor and chair of the department of neurology at the U-M Medical School. Fink developed the vector with collaborators and will direct the study.
The researchers are recruiting 12 patients with intractable pain from cancer for this study. For more information, contact the U-M Cancer AnswerLine, 800-865-1125.Image: Caption: The gene transfer vector (left) is injected into the skin in the area of pain (red line, right). From the skin, the vector is carried into sensory nerves and releases the inhibitory neurotransmitter locally in the spinal cord (red oval). Credit: University of MichiganSee full article.
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New Tuberculosis Vaccine Goes Into Clinical Trials

After 80 years, a new live vaccine against tuberculosis enters clinical trials this week. The new vaccine, VPM1002, is based on a vaccine that has been in use since 1921, and has been genetically engineered to prevent infection with tuberculosis bacteria much more effectively than its predecessor."The BCG tuberculosis vaccine, which was developed by French researchers, is the most frequently administered live vaccine in the world," says Kaufmann. However, BCG (short for the bacterium Bacillus Calmette-Guérind) is now frequently ineffective. The immunologist continues: "BCG has become a blunt weapon. We wanted to use genetic engineering to sharpen it so that, rather than hiding from the human immune system, it would stimulate it as much as possible.""The vaccine bacteria are taken up by the scavenger cells of the human immune system and end up in their digestion chambers. The genetically engineered modification allows them to escape from the chambers and arm the immune system against the tuberculosis pathogens."
The new vaccine has been developed at the Max Planck Institute for Infection Biology. In 2004, the vaccine was licensed to the Hanover-based VPN, which expedited the clinical study.Photo: Mycobakterium tuberculosis, Credit: Brinkmann/Schaible, MPI for Infection BiologySee full article.
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Photo courtesy of iStockphoto, Stephanie Horrocks Researchers have designed a nano-sized "trojan horse" particle to aid in the absorption of antioxidants in the gut by protectin antioxidants from enzyme and acid breakdown.The solution is to design a tiny sponge-like chitosan links

biopolymeric nanoparticle as a protective vehicle for antioxidants. Chitosan is a natural substance found in crab shells."Antioxidants sit within this tiny trojan horse, protecting it from attack from digestive juices in the stomach," Dr Larson said."Once in the small intestine the nanoparticle gets sticky and bonds to the intestinal wall. It then leaks its contents directly into the intestinal cells, which allows them to be absorbed directly into the blood stream."We hope that by mastering this technique, drugs and supplements also vulnerable to the digestive process can be better absorbed by the human body."
Clinical trials are slated for early next year.See full article.
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Greater experimental insight through development of more comprehensive data sets through automated parallel experimentation than can be achieved through traditional manual processes.
Use as instructed. Take medications according to your doctor's instructions.An XM

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