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Tabebuia impetiginosa Extract May Help Reduce Obesity, Diabetes and Heart Disease Risks

Using rats as animal models, scientists have been able to demonstrate that extracts derived from the Central and South American-native plant Tabebuia impetiginosa (also known as Pink Ipê or Pink Lapacho) can block dietary fat absorption, and thus reduce the risks of obesity, type 2 diabetes and coronary heart disease.Dr Roos and his team have shown that Tabebuia extract can reduce levels of triglycerides, a breakdown product of fat, in rats after they have been fed a fatty meal. "This result shows the extract may have a potential use in treating obesity," he observes. "However, as coronary heart disease and diabetes have also been shown to be associated with higher triglyceride levels after eating, we believe a food-supplement based on Tabebuia could reduce the incidence of these diseases as well. What is more, as obesity in developing countries is also on the increase, such extracts, taken as a capsule or added to food, may be a cheaper alternative for the rural population to pharmaceuticals."The data has been presented at the Society for Experimental Biology's Annual Meeting in Marseille last month and a paper is currently in press. The researchers say that futher studies will be conducted to identify the active compounds in the extracts.SourceSee full article.
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Doctors Lack Smoking Cessation Training (HealthDay)
HealthDay - MONDAY, Oct. 27 (HealthDay News) -- Few doctors or other health-care providers have enough smoking cessation training to help their patients quit smoking, a U.S. study suggests.An XM
Exercise may improve function in dementia patients (Reuters)
Reuters - Organized exercise designed to increase strength, flexibility, mobility and coordination may improve overall physical function among nursing home patients with Alzheimer's disease, researchers report.
Mustard Seed Meal as Herbicide

Photo courtesy of iStockphoto, Marcus LindströmMustard seed meal (MSM), a by-product of the extraction of mustard oil, has been demonstrated to be effective as an herbicide in container-grown ornamental plants.MSM applied to the soil surface of containers at 113, 225, and 450 g·m-2 reduced the number of annual bluegrass seedlings by 60%, 86%, and 98%, respectively, and the number of common chickweed seedlings by 61%, 74%, and 73%, respectively, at eight weeks after treatment. "Surface-applied MSM may control weeds in container-grown ornamentals without injuring the crop", summarized Boydston. In addition, MSM provides about five percent nitrogen and contributes to the nutrient needs of the crop.""MSM has the potential to be developed as a selective herbicide for annual weed control in ornamental containers and further research could identify additional tolerant and susceptible species of both weeds and ornamentals", Boydston noted. Cost may be a factor in the long-term use of MSM, he noted, adding, "Transportation of MSM from oil-crushing facilities to end users will be a major factor influencing the overall cost of MSM".SourceSee full article.
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OLive Leaf Extract Lower Cholesterol and Hypertension

Photo courtesy of iStockphoto, Image# 4790813In a trial involving sets of twins, a study published in Phytotherapy Research suggests that a 1000mg of a specific olive leaf links

extract (EFLA®943, Trademark: Benolea) can lower cholesterol and lower blood pressure in patients with mild hypertension (high blood pressure).To test this in humans, researchers from Switzerland and Germany conducted a pilot trial with 20 identical (monozygotic) twin pairs who had an increased blood pressure. Individuals were either given placebo capsules or capsules containing doses of 500mg or 1000mg of olive leaf extract EFLA®943. Pairs of twins were assigned to different treatments. After the subjects had taken the extract for eight weeks researchers measured blood pressures as well as collecting data about aspects of life-style.The study used Frutarom's EFLA943 olive leaf extract, and the company also funded the study.SourceSee full article.
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Beta-alanine helps seniors stave off fatigue (Reuters)
Reuters - Older people taking a sports nutrition supplement favored by Olympic athletes show substantial increases in their ability to withstand fatigue, new research shows.
Protein Biomarkers in Urine for Bovine Spongiform Encephalopathy (BSE)

Protein Biomarkers in Urine for Bovine Spongiform Encephalopathy (BSE)

6961047Photo courtesy of iStockphoto, Rob BroekResearchers have identified proteins in urine samples which may be used as an indicator of the presence and progress of Bovine Spongiform Encephalopathy (BSE) disease in cattle.The scientists analysed the proteins in urine samples taken from four infected and four healthy cows of the same age over the course of the disease. The proteins from the healthy and infected samples were compared using a technique called two-dimensional differential-gel electrophoresis (2-D DIGETM)In these preliminary results a single protein was able to distinguish between those infected and control animals. In addition, the relative abundance of a set of proteins could accurately determine how far the disease had advanced.
The researchers say these findings, published in the journal Proteome Science, may be used to develop a biomarker test for the diagnosis and monitoring of disease progression in BSE and related transmissible spongiform encephalopathies. SourceSee full article.
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Photo courtesy of iStockphoto, Image# 6892306Researchers are exploring the potential of olive stones, otherwise a waste product of the olive processing industry, as a substrate for bioethanol production. The stones are rich in polysaccharides (cellulose and hemicellulose) that can be broken down into sugar and then fermented to produce ethanol.In a pilot study, the olive stones were pre-treated using high-pressure hot water before the addition of enzymes which degrade plant matter and generate sugars. The hydrolysate obtained from this process was then fermented with yeasts to yield about 5.7 kg of ethanol per 100kg of olive stones.See full article.
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Cardiosphere-Derived Stem Cells for Treatment of Heart Disease

Photo courtesy of iStockphoto, Aaliya LandholtDuring the recently held Southern California BioMedical Council (SoCalBio or SCBC) 10th Investor Conference, biotech firm Capricor Inc presented their Cardiosphere-derived Stem Cells or CDC technology, and the multi-billion dollar market potential for heart therapies using CDC. "CDCs are the perfect stem cells to treat heart attacks and chronic heart failure" said Foellmer [President and CEO]. " Our stem cells are easily accessible from the patient themselves, readily grown in large numbers, and have proven themselves extremely safe. Unlike embryonic stem cells, there are no ethical or moral quandaries. And unlike other adult stem cells, such as bone marrow stem cells, our CDCs actually regrow cardiac muscle and vasculature. In short, CDCs have great potential for patients with a recent heart attack or chronic heart failure and we eagerly look forward to our imminent clinical trials."Capricor Inc. is headquartered in Los Angeles, California, and specializes in discovering, developing, and commercializing biotherapeutics for the treatment of heart diseases. See their products currently under clinical trials.See full article.
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New Tuberculosis Vaccine Goes Into Clinical Trials

After 80 years, a new live vaccine against tuberculosis enters clinical trials this week. The new vaccine, VPM1002, is based on a vaccine that has been in use since 1921, and has been genetically engineered to prevent infection with tuberculosis bacteria much more effectively than its predecessor."The BCG tuberculosis vaccine, which was developed by French researchers, is the most frequently administered live vaccine in the world," says Kaufmann. However, BCG (short for the bacterium Bacillus Calmette-Guérind) is now frequently ineffective. The immunologist continues: "BCG has become a blunt weapon. We wanted to use genetic engineering to sharpen it so that, rather than hiding from the human immune system, it would stimulate it as much as possible.""The vaccine bacteria are taken up by the scavenger cells of the human immune system and end up in their digestion chambers. The genetically engineered modification allows them to escape from the chambers and arm the immune system against the tuberculosis pathogens."
The new vaccine has been developed at the Max Planck Institute for Infection Biology. In 2004, the vaccine was licensed to the Hanover-based VPN, which expedited the clinical study.Photo: Mycobakterium tuberculosis, Credit: Brinkmann/Schaible, MPI for Infection BiologySee full article.
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New Scientific Journal: EMBO Molecular Medicine

Photo courtesy of iStockphoto, Andrey ProkhorovThe European Molecular Biology Organization (EMBO)will launch a new journal focusing on the interface between molecular biology and clinicalresearch. The EMBO Molecular Medicine journal, to be released starting 2009, will publish studies on molecular insights into cellular and systemic processes underlying defined human diseases as well as potential clinical applications for diagnosis, prevention and therapy."EMBO Molecular Medicine offers a unique opportunity to broadly distribute new findings in biomedical research and to strengthen links between clinicians and molecular biologists," said Hermann Bujard, EMBO Director. "We hope that published papers will lead to advances that will improve the detection, diagnosis and clinical management of diseases."Submissions are invited from research groups at universities, independent research laboratories and pharmaceutical and biotechnology companies worldwide.Research groups from universities, independent research institutions and pharma/biotech companies are invited to submit their manuscripts for publication. The journal offers free access to all content for the first two years of publication.See full article.
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Aquatic Garden Plants In WasteWater Treatment

Photo courtesy of iStockphoto, Miguel LamielIn a report published in HortScience, researchers show the potential of constructed wetlands as a simple, low-technology method for treating agricultural, industrial, and municipal wastewater. They investigated the nitrogen and phosphorus removal potential by a vegetated, laboratory-scale subsurface flow system. Instead of traditional wetland plants, however, they used commercially available aquatic garden plants, with promising results:Over an 8-week period, five commercially available aquatic garden plants received a range of N and P (0.39 to 36.81 mg·L-1 N and 0.07 to 6.77 mg·L-1 P) that spanned the rates detected in nursery runoff. Whole plant dry weight was positively correlated with N and P supplied. Highest N and P recovery rates were exhibited by Thalia geniculata f. rheumoides Shuey and Oenenathe javanica (Blume) DC. 'Flamingo', Phyla lanceolata (Michx.) Greene also had high P recovery rates. The potential exists for using SSF CWs to concomitantly produce aquatic garden plants and attenuate nutrients in a sustainable nursery enterprise.They conclude that aquatic garden plants are aesthetic and economically viable alternatives to traditional wetland plants in constructed wetlands.See full article.
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Jasmine Flower-Derived Substance, Potential New Anti-Cancer?

Photo courtesy of iStockphoto, Grigory Bibikov Research findings lead by Prof. Eliezer Flescher of The Sackler Faculty of Medicine, Tel Aviv University reported that a compound derived from the jasmine flower could be the key to a new effective therapy for cancer treatment.The substance, known as jasmonate (or methyl jasmonate) has been found to be responsive to blood cancers and solid tumors as demonstrated in preclinical studies and early first-in-man studies.According to Prof. Fletcher:"The jasmonate compound is used widely in agriculture and in cosmetics. Proven to be non-toxic, it has the same regulatory status as table salt. That and the fact we are working on a natural chemical gives us a good starting point for launching a new drug."The jasmine-based cancer drug is being developed by Sepal-Pharma (licensed Fletcher's research from Ramot, the technology transfer arm of Tel Aviv University) - a promising new biotech company where Fletcher serves on the advisory board links

.The said drug is targeted to be on the US market within the next four years.Read more from American Friends of Tel Aviv University.See full article.
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